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764582

Sigma-Aldrich

Polyethylenimine, linear

average Mn 5,000, PDI ≤1.3

Synonym(s):

PEI

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About This Item

Linear Formula:
(CH2CH2NH)n
CAS Number:
9002-98-6
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

Quality Level

100

mol wt

average Mn 5,000

mp

54-59 °C

PDI

≤1.3

storage temp.

2-8°C

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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General description

All polyethylene imine polymers are hydrophilic and may contain approx. 30% hydrated water.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCD4417
MKCC0935
MKBT7328V
MKBR6602V
MKBL7822

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Prashanth K B Nagesh et al.
Cancers, 10(9) (2018-08-29)
The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. Previous studies have shown that miR-205 negatively regulates prostate cancer cell proliferation, metastasis, and drug resistance. However, the delivery of miR-205 is an unmet
Laura R H Ip et al.
Oncotarget, 6(12), 10548-10562 (2015-04-15)
Treatment options for ovarian cancer patients remain limited and overall survival is less than 50% despite recent clinical advances. The lipid phosphatase inositol polyphosphate 4-phosphatase type II (INPP4B) has been described as a tumor suppressor in the PI3K/Akt pathway with

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This review will focus on the sub-sector of drug delivery concerning the delivery of nucleic acids, with a particular focus on poly(ethyleneimine).

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Recent Progress on Nonviral Delivery Carriers for CRISPR/Cas9 Systems

The CRISPR/Cas9 system has recently emerged as a highly specific, efficient, and versatile gene editing technology that can be utilized to build disease models and correct diseased genes. Safe and effective delivery vectors for the CRISPR/Cas9 system are in critical need to enable clinical development and future applications of CRISPR/Cas9 systems. Professor Yang Liu summarizes recent progress in nonviral nanoparticle approaches for CRISPR/Cas9 delivery.

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