367001
4,4′,4′′-Trimethoxytrityl chloride
technical grade
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About This Item
Linear Formula:
(CH3OC6H4)3CCl
CAS Number:
Molecular Weight:
368.85
EC Number:
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
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grade
technical grade
Quality Level
form
powder
mp
146-148 °C (lit.)
functional group
chloro
SMILES string
COc1ccc(cc1)C(Cl)(c2ccc(OC)cc2)c3ccc(OC)cc3
InChI
1S/C22H21ClO3/c1-24-19-10-4-16(5-11-19)22(23,17-6-12-20(25-2)13-7-17)18-8-14-21(26-3)15-9-18/h4-15H,1-3H3
InChI key
OBFCMKPFILBCSQ-UHFFFAOYSA-N
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Application
4,4′,4″-Trimethoxytrityl chloride can be used:
- In one of the key synthetic steps for the preparation of two phosphoramidite building blocks.
- To prepare protein tagging molecule (3-[tris(4-methoxyphenyl)methylsulfanyl]propanoic acid by reacting with thioacetic acid.
- To prepare C-2 amino trimethoxytrityl substituted nucleoside, which is a key intermediate for the synthesis of nucleoside based capping agent.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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An effective method for the synthesis of the cap structure of eukaryotic messenger ribonucleic acids
Kamimura T, et al.
Tetrahedron Letters, 25(25), 2683-2686 (1984)
Novel reagents for terminal phosphorylation and thiophosphorylation of synthetic oligonucleotides
Guzaev AP and Manoharan M
Tetrahedron Letters, 42(29), 4769-4773 (2001)
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