58169AST
CHIRALPAK® AGP HPLC Column
5 μm particle size, L × I.D. 5 cm × 3 mm
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Recommended Products
material
stainless steel column
Quality Level
Agency
suitable for USP L41
product line
CHIRALPAK®
packaging
pkg of 1 ea
manufacturer/tradename
CHIRALPAK®
parameter
137 bar pressure (2000 psi)
20-30 °C temperature
40 °C max. temp.
technique(s)
HPLC: suitable
L × I.D.
5 cm × 3 mm
matrix
fully porous particle
matrix active group
glycoprotein, alpha1- phase
particle size
5 μm
operating pH
2-8
separation technique
chiral
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General description
Hermansson described the use of natural proteins immobilized onto a silica support for chiral separations in 1983 (1). Proteins contain a large number of chiral centers of one configuration, and many other sites that contribute to the general retention process. CHIRALPAK AGP has the broadest range of selectivity of all protein phases currently available. CHIRALPAK AGP phase uses α1-acid glycoprotein (AGP) as the chiral selector immobilized on spherical 5 μm silica particles. Bonded AGP is a very stable protein that tolerates pure organic solvents, elevated temperatures and pH values from 4 to 7. Operated in reversed-phase mode, CHIRALPAK AGP column separates enantiomers of an extremely broad range of drug substances, such as acids, amines and neutral compounds. The enantioselectivity and retention can easily be regulated by mobile phase pH and ionic strength, and the nature and concentration of the organic modifier.
Features:
(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.
Features:
- Direct reversed phase resolution of chiral molecules
- Stable with a variety of organic modifiers
- Available in analytical and semi-preparative sizes
(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.
Legal Information
CHIRALPAK is a registered trademark of Daicel Corp.
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