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T1892

Sigma-Aldrich

Thioflavine S

Practical grade, powder

Synonym(s):

Direct Yellow 7

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About This Item

CAS Number:
1326-12-1
Colour Index Number:
49010
EC Number:
215-418-0
MDL number:
MFCD00071453
UNSPSC Code:
12171500
NACRES:
NA.47

product name

Thioflavine S, practical grade

grade

practical grade

Quality Level

200

form

powder

color

light beige to dark beige, to Dark Brown

solubility

ethanol: water (1:1): 1 mg/mL

λmax

360-380

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

General description

Thioflavine S aids in staining and visualizing β-amyloid plaques in Alzheimer′s disease. Thioflavin S binds to fibrillar β-amyloid plaques, and does not diffuse in the plaques. Thioflavin-S staining aids in visualizing smaller plaques throughout the neocortex, hippocampus and thalamic region.

Application

Thioflavine S has been used to stain and visualize β-amyloid structures in the tissue sections.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
Racke MM, et al.
The Journal of Neuroscience, 25(3), 629-636 (2005)
Disha Shah et al.
PloS one, 8(12), e84241-e84241 (2013-12-21)
Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it
Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity
Yuan P and Grutzendler J
The Journal of Neuroscience, 36(2), 632-641 (2016)
Genetic modulation of soluble A beta rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease
Fowler SW, et al.
The Journal of Neuroscience, 34(23), 7871-7885 (2014)
Farah H Bardai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(1), 108-119 (2017-11-16)
The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), which is caused by mutations in tau.
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