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SML2502

Sigma-Aldrich

MF-095

≥98% (HPLC)

Synonym(s):

(S)-N-(1-((5-(N-(tert-butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclopropanecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C27H31N3O4S
CAS Number:
2241021-89-4
Molecular Weight:
493.62
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NC(C)(C)C)c1c2c(c(ccc2)NC(=O)[C@@H](NC(=O)C4CC4)Cc3ccccc3)ccc1

InChI key

JSNVUWHDPLJARW-QHCPKHFHSA-N

Biochem/physiol Actions

MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30 (USP30)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Arthur F Kluge et al.
Bioorganic & medicinal chemistry letters, 28(15), 2655-2659 (2018-06-25)
Mitophagy is one of the processes that cells use to maintain overall health. An E3 ligase, parkin, ubiquitinates mitochondrial proteins prior to their degradation by autophagasomes. USP30 is an enzyme that de-ubiquitinates mitochondrial proteins; therefore, inhibiting this enzyme could foster

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