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Key Documents

SAB5702322

Sigma-Aldrich

Anti-ACLY Antibody, clone 8A0V0, Rabbit Monoclonal

Synonym(s):

ACL, ATPCL, CLATP

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

Quality Level

material

colorless

clone

8A0V0, monoclonal

form

liquid

species reactivity

human, rat, rat

concentration

0.26 mg/mL

technique(s)

immunofluorescence: 1:50 - 1:200
immunoprecipitation (IP): 1:50 - 1:200
western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

General description

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1000-1101 of human ACLY (P53396).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IF/ICC, IP

Storage Class Code

10 - Combustible liquids

WGK

WGK 1


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