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Key Documents

SAB4504393

Sigma-Aldrich

Anti-phospho-eNOS (pSer1176) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-ECNOS, Anti-eNOS

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 133 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

P29474

UniProt accession no.

P29474

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer1176)

Gene Information

human ... NOS3(4846)

General description

Nitric oxide synthase 3 (NOS3), also known as endothelial nitric oxide synthase (eNOS), is encoded by the gene mapped to human chromosome 7q35-36. The gene consists of 26 exons.

Immunogen

The antiserum was produced against synthesized peptide derived from human eNOS around the phosphorylation site of Ser1176.

Immunogen Range: 1144-1193

Biochem/physiol Actions

Nitric oxide synthase 3 (NOS3) has been studied as a modulator of vascular function and is involved in the production of nitric oxide. Defects in the enzyme expression have been shown to be associated with coronary artery disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Association between three eNOS polymorphisms and intracranial aneurysms risk: a meta-analysis.
Yang C, et al.
Medicine, 94(4) (2015)
Association between three eNOS polymorphisms and intracranial aneurysms risk: a meta-analysis.
Yang C, et al.
Medicine, 94(4) (2015)
Marwa Ben Ali et al.
Genetic testing and molecular biomarkers, 19(4), 203-208 (2015-03-10)
Nitric oxide (NO), produced by the enzyme endothelial nitric oxide synthase (eNOS), has critical roles in the regulation of vascular homeostasis and prevention of atherogenesis by inhibiting leukocytes, platelet activation, and smooth muscle cell proliferation. There is strong experimental and
Sherif Hafez et al.
Translational stroke research, 11(4), 851-860 (2019-12-21)
Physical exercise is known to reduce cardiovascular risk but its role in ischemic stroke is not clear. It was previously shown that an acute single bout of exercise reduced increased eNOS activation in the heart and reduced myocardial infarction. However
Bing Yi et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(10), 2153-2160 (2015-08-22)
Endothelial nitric oxide synthase (eNOS) is an important regulator of vascular function and its expression is regulated at post-transcriptional levels through a yet unknown mechanism. The purpose of this study is to elucidate the post-transcriptional factors regulating eNOS expression and
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