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Key Documents

SAB4502945

Sigma-Aldrich

Anti-Telomerase antibody produced in rabbit

affinity isolated antibody

Synonym(s):

EST2, HEST2, TCS1, Telomerase catalytic subunit, Telomerase reverse transcriptase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 126 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI accession no.

O14746

UniProt accession no.

O14746

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TERT(7015)

General description

Anti-Telomerase Antibody detects endogenous levels of total Telomerase protein.
The TERT (telomerase reverse transcriptase) gene is mapped to human chromosome 5p15.33 and encodes for a ribonucleoprotein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Telomerase.

Immunogen Range: 796-845

Biochem/physiol Actions

TERT (telomerase reverse transcriptase) catalyzes the de novo synthesis of telomere and results in cellular immortalization to maintain chromosomal stability. Mutations in TERT causes different types of malignancies such as gliomas, gastric cancer, and anaplastic thyroid cancer. Therefore, TERT serves as an early prognostic biomarker.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Silencing of hTERT blocks growth and migration of anaplastic thyroid cancer cells.
Maggisano V
Molecular and Cellular Endocrinology, 448, 34-40 (2017)
The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.
Carkic J
Journal of Oral Science, 58(4), 449-458 (2016)
Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas.
Fan X
Journal of Neuro-Oncology, 28(3), 455-462 (2016)
Lung cancer susceptibility locus at 5p15.33.
McKay JD
Nature Genetics, 40(12), 1404-1406 (2008)
Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression.
Tang B
Oncotarget, 7(10), 11364-11379 (2016)
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