M2199

PMEG hydrate

≥98% (HPLC)

• Synonym(s): 9-[2-(Phosphonomethoxy)ethyl]guanine hydrate
• Empirical Formula (Hill Notation): C₈H₁₂N₅O₅P · xH₂O
• CAS Number: 1255517-79-3
• Molecular Weight: 289.19 (anhydrous basis)
• MDL number: MFCD19443863
• UNSPSC Code: 12352202
• PubChem Substance ID: 329817932
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1
• InChI: 1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2
• InChI key: BDVQXHFCXJXVND-UHFFFAOYSA-N

Description

Biochem/physiol Actions

The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3