I4034
Immepip dihydrobromide
≥97% (HPLC), powder
Synonym(s):
4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
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About This Item
Empirical Formula (Hill Notation):
C9H17N3Br2
CAS Number:
Molecular Weight:
327.06
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
Assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
Br.Br.C1CNCC(C1)Cc2c[nH]cn2
InChI
1S/C9H15N3.2BrH/c1-2-8(5-10-3-1)4-9-6-11-7-12-9;;/h6-8,10H,1-5H2,(H,11,12);2*1H
InChI key
FXFINNKFZKZVLS-UHFFFAOYSA-N
Biochem/physiol Actions
Immepip is a H3 and H4 histamine receptor agonist. Immepip is a selective H3 agonist equipotent to (R)-α-methylhistamine and also effective in vitro and in vivo. It is devoid of side activities elicited at H1 and α2 receptors and 5-HT3 receptors.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Guadalupe-Elide Morales-Figueroa et al.
Purinergic signalling, 15(1), 85-93 (2018-12-20)
We previously reported that the activation of histamine H3 receptors (H3Rs) selectively counteracts the facilitatory action of adenosine A2A receptors (A2ARs) on GABA release from rat globus pallidus (GP) isolated nerve terminals (synaptosomes). In this work, we examined the mechanisms
Jitendra K Singh et al.
Annals of neurosciences, 19(2), 71-75 (2012-04-01)
The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic functions. This receptor exhibits molecular, pharmacological, and functional heterogeneity that affects
Alberto Avila-Luna et al.
Psychopharmacology, 236(6), 1937-1948 (2019-02-15)
Histamine H3 receptors (H3Rs) are co-expressed with dopamine D1 receptors (D1Rs) by striato-nigral medium spiny GABAergic neurons, where they functionally antagonize D1R-mediated responses. We examined whether the chronic administration of the H3R agonist immepip modifies dyskinesias induced by L-3,4-dihydroxyphenylalanine, L-Dopa
Cecilia Flores-Clemente et al.
Neuroscience letters, 641, 77-80 (2017-01-28)
There is evidence for genetic polymorphism within the human histamine H
Balasubramaniam Annamalai et al.
ACS chemical neuroscience, 11(3), 466-476 (2020-01-10)
Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have been attributed to robust SERT activity. H3 histamine receptors (H3Rs)
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