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I2285

Sigma-Aldrich

IPA-3

≥95% (HPLC), powder

Synonym(s):

1,1′-Disulfanediyldinaphthalen-2-ol

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About This Item

Empirical Formula (Hill Notation):
C20H14O2S2
CAS Number:
42521-82-4
Molecular Weight:
350.45
MDL number:
MFCD00388917
UNSPSC Code:
12352200
PubChem Substance ID:
329815364
NACRES:
NA.77

Quality Level

200

Assay

≥95% (HPLC)

form

powder

color

off-white to yellow

solubility

DMSO: >20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34

InChI

1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H

InChI key

RFAXLXKIAKIUDT-UHFFFAOYSA-N

Biochem/physiol Actions

IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H318 - H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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