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D6946

Sigma-Aldrich

(R)-DRF053 hydrochloride hydrate

≥98% (HPLC)

Synonym(s):

2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C23H27N7O · xHCl · yH2O
Molecular Weight:
417.51 (anhydrous free base basis)
MDL number:
MFCD17215921
UNSPSC Code:
12352200
PubChem Substance ID:
329798839
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c3ccccn3)c4ncn(C(C)C)c4n1

InChI

1S/C23H27N7O.ClH.H2O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);1H;1H2/t17-;;/m1../s1

InChI key

ZOSNTFVWVJFXQO-ZEECNFPPSA-N

Biochem/physiol Actions

DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mikołaj Słabicki et al.
Nature, 585(7824), 293-297 (2020-06-05)
Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid depletion of previously inaccessible targets2. They are clinically

Articles

Cyclin-dependent Kinases (CDKs)

Cyclin dependent kinases (CDKs) are typical serine/threonine kinases that display the 11 subdomains shared by all kinases. The complete sequence of the Homo sapiens genome shows that among the ~30,000 predicted genes, there are 13 CDKs and 25 cyclins. Eleven CDKS and their associated cyclins have been characterized in man.

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