31389
Dextran from Leuconostoc spp.
Mr ~40,000
Synonym(s):
DEXTRAN 40
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About This Item
Linear Formula:
(C6H10O5)n
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25
Recommended Products
biological source
(Leuconostoc spp)
Quality Level
form
powder
mol wt
Mr ~40,000
technique(s)
cryopreservation: suitable
gel permeation chromatography (GPC): suitable
loss
≤7% loss on drying
color
white
mp
483 °C ((901 °F ))
solubility
water: 1.5, clear, colorless
absorption
≤0.05 at 375 nm in H2O at 10%
suitability
suitable for additive or modifier in the separation of proteins or peptides
application(s)
advanced drug delivery
agriculture
sample preparation
storage temp.
room temp
InChI
1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2
InChI key
FZWBNHMXJMCXLU-UHFFFAOYSA-N
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General description
Dextrans belong to the category of polysaccharides primarily consisting of glucose units, specifically D-glucose units connected by alpha-(1-6) linkages. Their high molecular weight and specific structure depend on the microbial strain responsible for their production. These homopolysaccharides are produced through the action of extracellular dextransucrase enzymes, commonly found in lactic acid bacteria genera such as Leuconostoc, Lactobacillus, Streptococcus, Weissella, and Pediococcus. Dextrans find applications in various fields, including biochemical, cell biology, drug delivery research, and gel electrophoresis, owing to their versatile properties.
Application
Dextran from Leuconostoc spp. has been used:
- to mix with embryo suspension in seawater to prepare the sample for cryo-imaging
- to immerse the tails of zebrafish larvae for cryoimmobilization
- in the synthesis of vinyl sulfone modified dextran (DX-VS)
- in the synthesis of methacrylate functionalized dextran via ester linkage (DX-O-MeA)
- as a supplement in NCTC-135 tissue culture medium to prepare the perfusion medium
Dextran is a branched glucan composed of linear α(1→6) linked glucose units and α (1→3) link initiated branches. Dextran ranges in size from 10,000 to 150,000 Kd. Dextrans are used in many applications as volume extenders, stabilizers, matrix components, binding platforms, lubricants, and physical structure components.
Dextran 40 is used in the development of new improved preservation solutions for organ transplantation. Dextran 40 may be used to determine cell tightness and flux parameters across cell layers. Dextran 40 is used as a colloidal plasma volume extender.
Dextran 40 is used in the development of new improved preservation solutions for organ transplantation. Dextran 40 may be used to determine cell tightness and flux parameters across cell layers. Dextran 40 is used as a colloidal plasma volume extender.
Biochem/physiol Actions
Osmotic Balance: Dextran helps maintain osmotic balance by increasing the solute concentration in a solution. This prevents excessive water movement across cell membranes, thus maintaining cell integrity and function.
-Cryoprotection: Dextran acts as a cryoprotectant by forming a protective barrier around cells and tissues during freezing. This barrier inhibits the formation of ice crystals, which can damage cell membranes and structures.
-Viscosity Control: Dextran can alter the viscosity of solutions by increasing the molecular weight of the solution. This change in viscosity affects the flow properties of the solution, making it useful for controlling the thickness of solutions in various processes.
-Drug Delivery: Modified dextran serves as a carrier for controlled drug delivery. Dextran can encapsulate drugs and release them gradually, enhancing drug solubility and controlling the release profiles to improve therapeutic outcomes.
-Gel Electrophoresis: Dextran increases the density of sample loading solutions in gel electrophoresis. This increased density helps samples sink into the gel matrix, allowing for more precise separation of molecules based on size and charge during electrophoresis.
-Enzyme Stabilization: Dextran stabilizes enzymes by providing a protective environment. It forms a stable matrix around enzymes, enhancing their activity and extending their lifespan in various biochemical reactions. This protection prevents enzyme denaturation and inactivation, allowing enzymes to function more effectively.
-Cryoprotection: Dextran acts as a cryoprotectant by forming a protective barrier around cells and tissues during freezing. This barrier inhibits the formation of ice crystals, which can damage cell membranes and structures.
-Viscosity Control: Dextran can alter the viscosity of solutions by increasing the molecular weight of the solution. This change in viscosity affects the flow properties of the solution, making it useful for controlling the thickness of solutions in various processes.
-Drug Delivery: Modified dextran serves as a carrier for controlled drug delivery. Dextran can encapsulate drugs and release them gradually, enhancing drug solubility and controlling the release profiles to improve therapeutic outcomes.
-Gel Electrophoresis: Dextran increases the density of sample loading solutions in gel electrophoresis. This increased density helps samples sink into the gel matrix, allowing for more precise separation of molecules based on size and charge during electrophoresis.
-Enzyme Stabilization: Dextran stabilizes enzymes by providing a protective environment. It forms a stable matrix around enzymes, enhancing their activity and extending their lifespan in various biochemical reactions. This protection prevents enzyme denaturation and inactivation, allowing enzymes to function more effectively.
Features and Benefits
- Dextran with an average molecular weight of 40,000
- Freely soluble in Water, DMSO, formamide, ethylene glycol, and glycerol
- Versatile and adaptable for various laboratory and research applications
Other Notes
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
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Netta Vidavsky et al.
Journal of structural biology, 196(3), 487-495 (2016-10-04)
Many important biological questions can be addressed by studying in 3D large volumes of intact, cryo fixed hydrated tissues (⩾10,000μm3) at high resolution (5-20nm). This can be achieved using serial FIB milling and block face surface imaging under cryo conditions.
Stefan D Gentile et al.
Frontiers in bioengineering and biotechnology, 8, 792-792 (2020-08-15)
The study of the liver progenitor cell microenvironment has demonstrated the important roles of both biochemical and biomechanical signals in regulating the progenitor cell functions that underlie liver morphogenesis and regeneration. While controllable two-dimensional in vitro culture systems have provided
Ana Bratuša et al.
Colloids and surfaces. B, Biointerfaces, 181, 561-566 (2019-06-12)
This work describes the derivatization of dextran using N-(tert-butyloxycarbonyl)-S-(trityl)-L-cysteine in the presence of N,N'-carbonyldiimidazole (CDI) as a coupling agent. Homogeneous reactions in dimethyl sulfoxide allowed for an efficient coupling of the amino acid derivative to the polymer backbone. Derivatization was
Marie Chollat-Namy et al.
Cell death & disease, 10(10), 695-695 (2019-09-22)
Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors
Non-adsorbing macromolecules promote endothelial adhesion of erythrocytes with reduced sialic acids.
Yang Yang et al.
Biochimica et biophysica acta, 1840(1), 288-293 (2013-10-01)
Abnormal adhesion of red blood cells (RBCs) to vascular endothelium is often associated with reduced levels of sialic acids on RBC membranes and with elevated levels of pro-adhesive plasma proteins. However, the synergistic effects of these two factors on the
Related Content
Learn about C6H10O6 or dextran formation, classes and naming from MilliporeSigma. Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, which have a linear backbone of α-linked d-glucopyranosyl repeating units.
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