S1878
Sodium (meta)periodate
≥99.0%
Synonym(s):
Sodium periodate
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About This Item
Linear Formula:
NaIO4
CAS Number:
Molecular Weight:
213.89
EC Number:
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.55
Assay:
≥99.0%
form:
powder
solubility:
H2O: 50 mg/mL
Recommended Products
Quality Level
Assay
≥99.0%
form
powder
reaction suitability
reagent type: oxidant
pH
3.5-5.5 (25 °C, 107 g/L)
solubility
H2O: 50 mg/mL
SMILES string
[Na+].[O-]I(=O)(=O)=O
InChI
1S/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1
InChI key
JQWHASGSAFIOCM-UHFFFAOYSA-M
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General description
Sodium (meta)periodate is commonly used as an oxidizing agent in organic synthesis for the oxidation of various organic substrates. It can also be used as a co-oxidant with other oxidizing reagents such as osmium tetroxide and potassium permanganate. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water.
Application
Sodium (meta)periodate can be used as an oxidizing agent for the oxidation of:
It can also be used in the:
- 1,2-diols to aldehydes or ketones via oxidative cleavage. Sulfides to sulfoxides in the presence of phase transfer catalysts.
- Diaryl, dialkyl, and aryl alkyl selenides to the respective selenoxides.
- Phenols and their derivatives to corresponding quinones.
- Acylphosphoranes to α,β-dicarbonyl compounds.
It can also be used in the:
- Selective alkene epoxidation and alkane hydroxylation,·
- Oxidation of carbohydrates.
- Iodination of aromatic compounds.
Useful reagent for the oxidation of carbohydrates prior to labeling with biotin hydrazide
Features and Benefits
NaIO4 is a stable, selective, and cost-effective reagent that is capable of reacting under mild conditions.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1C - STOT RE 1
Target Organs
Thyroid
Storage Class Code
5.1A - Strongly oxidizing hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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