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63187

Sigma-Aldrich

Methoxypolyethylene glycol maleimide

≥90% (NMR), 5,000

Synonym(s):

Polyethylene glycol, MeO-PEG-Mal, PEG-maleimide, mono-Methyl polyethylene glycol 2-maleimidoethyl ether

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About This Item

CAS Number:
99126-64-4
MDL number:
MFCD00803681
UNSPSC Code:
12162002
PubChem Substance ID:
24882458
NACRES:
NA.25
Pricing and availability is not currently available.

Quality Level

200

Assay

≥90% (NMR)

mol wt

PEG average Mn 5,000

Ω-end

maleimide

α-end

methoxy

storage temp.

−20°C

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Methoxypolyethylene glycol maleimide ≥90% (NMR), 5,000

63187

Methoxypolyethylene glycol maleimide

Methoxypolyethylene glycol maleimide 750

712558

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Methoxypolyethylene glycol maleimide PEG average Mn 10,000 g/mol

712469

Methoxypolyethylene glycol maleimide

Methoxypolyethylene glycol 5,000 acetic acid N-succinimidyl ester ≥80%

85973

Methoxypolyethylene glycol 5,000 acetic acid N-succinimidyl ester

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

-

mol wt

PEG average Mn 5,000

mol wt

PEG average Mn 750

mol wt

PEG average Mn 10,000 g/mol

mol wt

PEG average Mn 5,000

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Ω-end

maleimide

Ω-end

maleimide

Ω-end

maleimide

Ω-end

NHS ester

α-end

methoxy

α-end

methoxy

α-end

methoxy

α-end

methoxy

Application

Methoxypolyethylene glycol maleimide (MeO-PEG-Mal) is used as a protein pegylation reagent. PEGylation is the process of covalently attaching polyethylene glycol (PEG) polymer chains to other molecule such as proteins.

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Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCG4268
    BCCF9590
    BCCF1722
    BCCC5726
    BCCB6191

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    Jiankun Qie et al.
    Drug metabolism letters, 1(3), 232-240 (2007-08-01)
    Site-specific mono-PEGylations were performed in different conformational regions of Thymosin alpha 1 (T alpha 1) by introducing one cysteine residue into the chosen site and coupling with thiol-specific mPEG-MAL reagent. Results demonstrated that PEGylated sites and regions influenced the conformations
    R J Goodson et al.
    Bio/technology (Nature Publishing Company), 8(4), 343-346 (1990-04-01)
    We have modified recombinant interleukin-2 (rIL-2) to facilitate site-directed covalent attachment of monomethoxy polyethylene glycol (PEG). The site chosen for modification and subsequent covalent attachment with PEG (PEGylation) was the single glycosylation position found in the native interleukin-2 (IL-2). The
    K Ananda et al.
    Analytical biochemistry, 374(2), 231-242 (2007-12-27)
    The design of the extension arm-facilitated PEGylation (EAFP) of proteins takes advantage of the high selective and quantitative aspects of the thiol-maleimide reaction. However, the efficiency of EAFP with hemoglobin varied with the batches of maleimide-PEG. The low level of
    Lidia Wrobel et al.
    Scientific reports, 6, 27484-27484 (2016-06-07)
    Disulfide bond formation is crucial for the biogenesis and structure of many proteins that are localized in the intermembrane space of mitochondria. The importance of disulfide bond formation within mitochondrial proteins was extended beyond soluble intermembrane space proteins. Tim22, a
    Leah C Ray et al.
    Nature chemical biology, 14(6), 538-541 (2018-05-18)
    Polyprenol phosphate phosphoglycosyl transferases (PGTs) catalyze the first membrane-committed step in assembly of essential glycoconjugates. Currently there is no structure-function information to describe how monotopic PGTs coordinate the reaction between membrane-embedded and soluble substrates. We describe the structure and mode
    View All Related Papers

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