MABN53
Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9
clone 3D9, from mouse
Synonym(s):
Dopamine D2 receptor
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All Photos(2)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
3D9, monoclonal
species reactivity
rat
species reactivity (predicted by homology)
human (immunogen homology)
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... DRD2(1813)
rat ... Drd2(24318)
General description
Problems in the CNS dopaminergic system are thought to be the root cause of some neuropsychiatric disorders. Dopamine D2 receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Dopamine D2 receptor signaling using Nurr1 and ERK may play an important role in mesencephalic dopaminergic neuronal development. Faulty D2 receptors have been common in cases of ROS-dependent hypertension. In addition, defects in DRD2 are associted with alcohol-responsive dystonia, varying susceptability to familial alcoholism as well as a contributing factor to the suicide risk in alcoholics.
Immunogen
Linear peptide corresponding to human Dopamine D2 receptor.
Application
Immunocytochemistry Analysis: A previous lot was used by an independent laboratory to detect Dopamine D2 receptor in Ntera-2 cells and in rat brain neurons. Courtesy of Glenn Morris, Wolfson Centre for Inherited Neuromuscular Disease.
This Anti-Dopamine D2 receptor (DRD2) Antibody, clone 2B9 is validated for use in WB, IC for the detection of Dopamine D2 receptor (DRD2).
Quality
Evaluated by Western Blot in rat spinal cord tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.
Target description
~50 kDa observed
Physical form
Format: Purified
Analysis Note
Control
Rat spinal cord tissue lysate
Rat spinal cord tissue lysate
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Endosomal location of dopamine receptors in neuronal cell cytoplasm.
Wolstencroft, EC; Simic, G; thi Man, N; Holt, I; Lam, le T; Buckland, PR; Morris, GE
Journal of Molecular Histology null
Wilber Romero-Fernandez et al.
Molecular neurobiology, 59(10), 5955-5969 (2022-07-14)
The adenosine A2A receptor (A2AR), dopamine D2 receptor (D2R) and metabotropic glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in living cells and in rat striatal neurons. In the current study, we present experimental data supporting the view that
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Dasiel O Borroto-Escuela et al.
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Neurochemical research, 45(1), 5-15 (2019-06-07)
G protein-coupled receptors modulate the synaptic glutamate and GABA transmission of the claustrum. The work focused on the transmitter-receptor relationships in the claustral catecholamine system and receptor-receptor interactions between kappa opioid receptors (KOR) and SomatostatinR2 (SSTR2) in claustrum. Methods used
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