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407286

Sigma-Aldrich

Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6)

liquid, clone 272-17E6, Calbiochem®

Synonym(s):

Anti-CD51

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

272-17E6, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ITGAV(3685)

General description

Purified mouse monoclonal antibody. Recognizes the αv integrin chain and all αv-containing integrins.
Recognizes the αv integrin chain and all αv-containing integrins.
This Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6) is validated for use in Cell Inhibition Assays, ELISA, FC, IP for the detection of Integrin αv (Ab-1).

Immunogen

Human
human placental αvβ₃ integrin

Application

Cell Inhibition Assays (see application reference)

ELISA (see application reference)

Flow Cytometry (2.5 µg/ml, see application reference)

Immunoprecipitation (2.5 µg/ml, see application reference)

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In PBS, pH 7.6.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Akiyama, S.K. 1996. Hum. Cell9, 181.
Hynes, R.O. 1992. Cell69, 11.
Albelda, S.M. and Buck, C.A. 1990. FASEB J.4, 2868.
Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol.3, 179.
Hynes, R.O. 1987. Cell45, 549.
Cross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Colin D H Ratcliffe et al.
Traffic (Copenhagen, Denmark), 17(6), 670-688 (2016-03-05)
The integrin family of cell adhesion receptors link extracellular matrices to intracellular signaling pathways and the actin cytoskeleton; and regulate cell migration, proliferation and survival in normal and diseased tissues. The subcellular location of integrin receptors is critical for their
Lan Nguyen et al.
Journal of biomolecular screening, 17(6), 835-842 (2012-04-05)
Alzheimer's disease (AD) is a devastating neurodegenerative disease affecting millions of people. The amyloid hypothesis suggests that the pathogenesis of AD is related to the accumulation of amyloid beta (Aβ) in the brain. Herein, the authors quantify Aβ-mediated changes in
Abdullah Karadag et al.
Cancer research, 65(24), 11545-11552 (2005-12-17)
The up-regulation of various matrix metalloproteinases (MMP), certain cell receptors such as integrins and CD44, and the SIBLING family of integrin-binding glycophosphoproteins have been reported separately and in various combinations for many types of tumors. The mechanisms by which these

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