1.06627

Sodium thiocyanate

EMPLURA^®

• Synonym(s): Sodium thiocyanate, Sodium sulfocyanide
• Empirical Formula (Hill Notation): CNNaS
• CAS Number: 540-72-7
• Molecular Weight: 81.07
• MDL number: MFCD00011123
• UNSPSC Code: 12352300
• EC Index Number: 208-754-4

Properties

• vapor pressure: <1 hPa ( 20 °C)
• Quality Level: 200
• product line: EMPLURA^®
• Assay: ≥98.5% dry basis (silver nitrate titration)
• form: solid
• potency: 764 mg/kg LD₅₀, oral (Rat)
• loss: ≤5.0% loss on drying, 105°C
• pH: 6-8 (20 °C, 100 g/L in H₂O)
• mp: 308 °C
• solubility: >1000 g/L
• density: 1.74 g/cm³ at 20 °C
• bulk density: 800‑1000 kg/m³
• anion traces: chloride (Cl^-): ≤0.1%; sulfate (SO₄^2-): ≤0.025%
• cation traces: As: ≤0.0005%; heavy metals (as Pb): ≤0.002%
• storage temp.: 2-30°C
• InChI: 1S/CHNS.Na/c2-1-3;/h3H;/q;+1/p-1
• InChI key: VGTPCRGMBIAPIM-UHFFFAOYSA-M

Description

Application

• Copper-mediated [3 + 2] oxidative cyclization of oxime acetate: Demonstrates the use of sodium thiocyanate in copper-mediated synthesis, crucial for the formal synthesis of fentiazac, highlighting its role in pharmaceutical synthesis techniques (Jadhao et al., 2024).


• Fabrication and Characterization of Flexible Solid Polymers Electrolytes for Supercapacitor Application: Details the application of sodium thiocyanate in the development of advanced polymer electrolytes for supercapacitors, emphasizing its impact on the energy storage sector (Badi et al., 2022).


• Lactose oxidase: An enzymatic approach to inhibit Listeria monocytogenes in milk: Utilizes sodium thiocyanate as part of a novel enzymatic strategy to enhance food safety, providing an alternative to traditional preservatives in dairy products (Flynn et al., 2021).


• 1,3-Dibromo-1,1-difluoro-2-propanone as a Useful Synthon for a Chemoselective Preparation of 4-Bromodifluoromethyl Thiazoles: Incorporates sodium thiocyanate in the synthesis of bromodifluoromethyl thiazoles, demonstrating its utility in the creation of novel compounds for chemical research and industrial applications (Colella et al., 2018).

Analysis Note

Assay (argentometric; calculated on dried substance): ≥ 98.5 %
Identity: passes test
Chloride (Cl): ≤ 0.1 %
Sulfate (SO₄): ≤ 0.025 %
Heavy metals (as Pb): ≤ 0.002 %
As (Arsenic): ≤ 0.0005 %
Loss on Drying (105°C): ≤ 5.0 %

Legal Information

EMPLURA is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302 + H312 + H332 - H318 - H412
• Precautionary Statements: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1
• Supplementary Hazards: EUH032
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable