07-617
Anti-mGluR1 Antibody
Upstate®, from rabbit
Synonym(s):
Anti-GPRC1A, Anti-MGLU1, Anti-MGLUR1, Anti-PPP1R85, Anti-SCA44, Anti-SCAR13
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All Photos(2)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... GRM1(2911)
Specificity
Predicted to cross-react with human and mouse based on sequence homology
mGluR1
Immunogen
peptide corresponding to amino acids 1180-1199 (C-PNVTYASVILRDYKQSSSTL) of rat mGluR1
Application
Anti-mGluR1 Antibody detects level of mGluR1 & has been published & validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurodegenerative Diseases
Neurotransmitters & Receptors
Neurodegenerative Diseases
Quality
routinely evaluated by immunoblot on mGluR1 in rat brain microsomal preparation
Target description
142kDa
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
Format: Purified
Protein A purified
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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F Ango et al.
Nature, 411(6840), 962-965 (2001-06-22)
G-protein-coupled receptors (GPCRs) transduce signals from extracellular transmitters to the inside of the cell by activating G proteins. Mutation and overexpression of these receptors have revealed that they can reach their active state even in the absence of agonist, as
M Sallese et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(15), 2569-2580 (2000-12-02)
G-protein-coupled receptor kinases (GRKs) are involved in the regulation of many G-protein-coupled receptors. As opposed to the other GRKs, such as rhodopsin kinase (GRK1) or beta-adrenergic receptor kinase (beta ARK, GRK2), no receptor substrate for GRK4 has been so far
D D Wright et al.
The Journal of comparative neurology, 364(4), 729-745 (1996-01-22)
We demonstrate that the metabotropic glutamate receptor mGluR1 alpha is enriched in two interneuron cell populations in the dorsal division of the cochlear nucleus. Electron microscopic analysis confirms that mGluR1 alpha immunoreactivity is concentrated in the dendritic spines of cartwheel
Glutamate and the glutamate receptor system: a target for drug action.
Bleich, Stefan, et al.
International Journal of Geriatric Psychiatry, 18, S33-S40 (2003)
L B Dale et al.
The Journal of biological chemistry, 275(49), 38213-38220 (2000-09-13)
Metabotropic glutamate receptors (mGluRs) constitute a unique subclass of G protein-coupled receptors (GPCRs) that bear little sequence homology to other members of the GPCR superfamily. The mGluR subtypes that are coupled to the hydrolysis of phosphoinositide contribute to both synaptic
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