934275

Pomalidomide-piperazine

≥ 95.0%

• Synonym(s): 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(1-piperazinyl)-2-(2,6-Dioxopiperidin-3-yl)-4-(piperazin-1-yl)isoindole-1,3-dione
• Empirical Formula (Hill Notation): C₁₇H₁₈N₄O₄
• CAS Number: 2154342-57-9
• Molecular Weight: 342.35
• MDL number: MFCD32898791
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• ligand: pomalidomide
• Quality Level: 100
• Assay: ≥ 95.0%
• form: powder or crystals
• color: faint yellow to dark yellow
• storage temp.: 2-8°C
• SMILES string: O=C1NC(=O)C(N2C(=O)C3=CC=CC(=C3C2=O)N4CCNCC4)CC1

Description

Application

A functionalized cereblon ligand for development of Pomalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination; and a basic building block for making protein degrader library.

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Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations; Inc.; and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360D
• Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable