924083
TAMRA-a-TCO
Synonym(s):
(R,E)-2-(6-(Dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)-5-((5-(2-(1-hydroxycyclooct-4-en-1- yl)acetamido)pentyl)carba
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C40H48N4O6
Molecular Weight:
680.83
reaction suitability
reaction type: click chemistry
reagent type: chemical modification reagent
reagent type: fluorescent-labelling reagent
Quality Level
storage temp.
−20°C
Application
TAMRA-a-TCO is an axial trans-cyclooctene (a-TCO) for bioconjugation and protein labeling. As demonstrated by the Joe Fox lab in Pigga, et al, a-TCOs are more hydrophilic and reactive than standard TCOs. The fluorescent TAMRA-a-TCO was developed for rapid, live-cell and in vivo experiments. It is cell permeable, reacts with tetrazines intracellularly via Diels-Alder chemistry, and exhibits reduced background fluorescence relative to other TAMRA TCO tags when imaged using fluorescence microscopy (illumination at λ=531 nm).
Other new a-TCOs:
Other new a-TCOs:
- NHS ester-a-TCO (MKE211512)
- Alkyne-a-TCO (MKE211515)
- Amine-a-TCO (MKE211516)
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service