761516
Dibenzocyclooctyne-acid
95%, storage temp.:-20°C
Synonym(s):
DBCO-Acid
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
Quality Level
Assay
95%
form
solid
reaction suitability
reaction type: click chemistry
reagent type: linker
mp
118-125 °C
functional group
carboxylic acid
storage temp.
−20°C
SMILES string
O=C(CCCCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3
InChI
1S/C21H19NO3/c23-20(11-5-6-12-21(24)25)22-15-18-9-2-1-7-16(18)13-14-17-8-3-4-10-19(17)22/h1-4,7-10H,5-6,11-12,15H2,(H,24,25)
InChI key
NIRLBCOFKPVQLM-UHFFFAOYSA-N
General description
Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Application
Dibenzocyclooctyne-acid may be used for the surface modification of eight-arm poly(ethylene glycol), to make it susceptible to strain promoted alkyne-azide cycloaddition (SPAAC) with PEG-bis-azide leading to the formation of hydrogels. These hydrogels are useful for protein immobilization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Bio-orthogonal conjugation and enzymatically triggered release of proteins within multi-layered hydrogels.
Acta Biomaterialia (2017)
Neuroendocrine Tumor?Targeted Upconversion Nanoparticle?Based Micelles for Simultaneous NIR?Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging.
Advances in Functional Materials, 27(8) (2017)
A `catch and release?strategy towards HPLC-free purification of synthetic oligonucleotides by a combination of the strain-promoted alkyne-azide cycloaddition and the photocleavage.
Bioorganic & Medicinal Chemistry (2017)
Near-infrared light-triggered thermochemotherapy of cancer using a polymer?gold nanorod conjugate.
Nanotechnology, 27(17), 175102-175102 (2016)
Flexible synthesis of cationic peptide?porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.
Organic & Biomolecular Chemistry, 14(48), 11488-11501 (2016)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service