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527858

Sigma-Aldrich

Aldolase Antibody 84G3, murine catalytic monoclonal antibody

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.22

antibody product type

primary antibodies

Quality Level

storage temp.

−20°C

target post-translational modification

unmodified

Application

Novel biocatalyst for aldol condensation, especially for the re-facial addition of aliphatic ketones to aldehydes. Antibody 84G3 catalyzes aldol, crossed aldol, retroaldol, decarboxylation of β-keto acids, self aldol, and Robinson annulations.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S C Sinha et al.
Organic letters, 1(10), 1623-1626 (2000-06-03)
[formula: see text] Three monoclonal aldolase antibodies, generated against a beta-diketone hapten by reactive immunization, catalyzed rapid and highly enantioselective retro-aldol reactions of ent-8a-k, providing optically pure 8a-k by kinetic resolution. Compounds (+/-)-8a, (+/-)-8g, and (+/-)-8k have been resolved in
Zhong et al.
Angewandte Chemie (International ed. in English), 38(24), 3738-3741 (2000-01-29)
Nine efficient aldolase antibodies were generated by using hapten 1. This hapten unites reactive immunization and the transition state analogue approach in a single molecule. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold

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