440736
4-Thiouracil
97%
Synonym(s):
2-Hydroxy-4-mercaptopyrimidine
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About This Item
Empirical Formula (Hill Notation):
C4H4N2OS
CAS Number:
Molecular Weight:
128.15
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
97%
form
powder
mp
295 °C (dec.) (lit.)
solubility
1 M NaOH: soluble 50 mg/mL
SMILES string
Oc1nccc(S)n1
InChI
1S/C4H4N2OS/c7-4-5-2-1-3(8)6-4/h1-2H,(H2,5,6,7,8)
InChI key
OVONXEQGWXGFJD-UHFFFAOYSA-N
Related Categories
Application
4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Structure and tautomerism of the neutral and monoanionic forms of 4-thiouracil derivatives.
A Psoda et al.
Journal of the American Chemical Society, 96(22), 6832-6839 (1974-10-30)
Michael R Miller et al.
Nature methods, 6(6), 439-441 (2009-05-12)
We found that the combination of spatially restricted uracil phosphoribosyltransferase (UPRT) expression with 4-thiouracil delivery can be used to label and purify cell type-specific RNA from intact complex tissues in Drosophila melanogaster. This method is useful for isolating RNA from
Jeanine S Morey et al.
PloS one, 8(6), e66347-e66347 (2013-06-19)
Dinoflagellates possess many physiological processes that appear to be under post-transcriptional control. However, the extent to which their genes are regulated post-transcriptionally remains unresolved. To gain insight into the roles of differential mRNA stability and de novo transcription in dinoflagellates
P J Unrau et al.
Nature, 395(6699), 260-263 (1998-09-29)
The 'RNA world' hypothesis proposes that early life developed by making use of RNA molecules, rather than proteins, to catalyse the synthesis of important biological molecules. It is thought, however, that the nucleotides constituting RNA were scarce on early Earth.
Xiaoran Zou et al.
The journal of physical chemistry. B, 118(22), 5864-5872 (2014-05-14)
Intensified research interests are posed with the thionucleobase 4-thiouracil (4-TU), due to its important biological function as site-specific photoprobe to detect RNA structures and nucleic acid-nucleic acid contacts. By means of time-resolved IR spectroscopy and density functional theory (DFT) studies
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