233234

3-Chloro-4-fluoronitrobenzene

98%

• Synonym(s): 2-Chloro-1-fluoro-4-nitrobenzene
• Linear Formula: ClC₆H₃(F)NO₂
• CAS Number: 350-30-1
• Molecular Weight: 175.54
• EC Number: 206-499-3
• MDL number: MFCD00007206
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853962
• NACRES: NA.22

Properties

• Assay: 98%
• form: solid
• mp: 40-42 °C (lit.)
• SMILES string: [O-][N+](=O)c1ccc(F)c(Cl)c1
• InChI: 1S/C6H3ClFNO2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H
• InChI key: DPHCXXYPSYMICK-UHFFFAOYSA-N

Description

General description

2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)₆ and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.

Application

2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:

• benzoimidolones on Ameba resin
• methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302 - H315 - H318 - H335
• Precautionary Statements: P261 - P280 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves