Skip to Content
Merck
All Photos(4)

Documents

212970

Sigma-Aldrich

2-(Bromomethyl)acrylic acid

98%

Synonym(s):

α-(Bromomethyl)acrylic acid, 2-(Bromomethyl)-2-propenoic acid, Bromomethylacrylic acid

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

Linear Formula:
CH2=C(CH2Br)COOH
CAS Number:
72707-66-5
Molecular Weight:
164.99
Beilstein:
2426204
EC Number:
276-774-0
MDL number:
MFCD00004259
UNSPSC Code:
12162002
PubChem Substance ID:
24852758
NACRES:
NA.23

Assay

98%

form

solid

mp

70-73 °C (lit.)

storage temp.

2-8°C

SMILES string

OC(=O)C(=C)CBr

InChI

1S/C4H5BrO2/c1-3(2-5)4(6)7/h1-2H2,(H,6,7)

InChI key

NOOYFQLPKUQDNE-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Reacts with aldehydes and ketones to form α-methylene-butyrolactones. Used in the synthesis of methotrexate analogues.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Synthesis, 530-530 (1990)
A Abraham et al.
Journal of medicinal chemistry, 34(1), 222-227 (1991-01-01)
Five analogues of methotrextate (MTX), 10-deazaaminopterin (10-DAM), and 10-ethyl-10-deazaaminopterin (10-EDAM) in which the glutamate moiety was replaced by either a gamma-methyleneglutamate or beta-hydroxyglutamate were synthesized and evaluated for their antifolate activity. These analogous are 4-amino-4-deoxy-N10-methylpteroyl-beta-hydroxyglutamic acid (1), 4-amino-4-deoxy-10-deazapteroyl-beta-hydroxyglutamic acid (2)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service