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14501

Sigma-Aldrich

Poly(ethylene glycol) bis(amine)

Mw 2,000, carboxyl reactive, amine

Synonym(s):

Polyethylene glycol, O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)

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About This Item

Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
24991-53-5
MDL number:
MFCD00132004
UNSPSC Code:
12162002
PubChem Substance ID:
24848541
NACRES:
NA.23

product name

Poly(ethylene glycol) bis(amine), Mw 2,000

form

powder

mol wt

Mw 2,000

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

−20°C

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

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Related Categories

Application


  • Polyethylene Glycol Conjugated Polymeric Nanocapsules for Targeted Delivery of Quercetin to Folate-Expressing Cancer Cells in Vitro and in Vivo: Discusses the use of PEG-bis amine for creating polymeric nanocapsules aimed at enhancing targeted drug delivery (RI El-Gogary et al., 2014).

Other Notes

Polymer for preparing enzyme conjugates soluble in organic solvents; Promising drug carrier

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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L Kelemen et al.
Lab on a chip, 19(11), 1985-1990 (2019-05-03)
Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free biosensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult.
K Kawasaki et al.
Chemical & pharmaceutical bulletin, 43(12), 2133-2138 (1995-12-01)
Hybrids of fibronectin-related peptides [Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser (RGDS)] and poly(ethylene glycol) (PEG) were prepared and their inhibitory effects on experimental metastasis in mice were examined. The inhibitory effect of RGD was markedly potentiated by hybrid formation with poly(ethylene glycol) #6000.
Urrotigoity, M. and Souppe, J.
Biocatalysis, 2, 145-145 (1989)
Takahiko Matsushita et al.
The Journal of organic chemistry, 71(8), 3051-3063 (2006-04-08)
A MUC1-related glycopeptide having five core-2 hexasaccharide branches (C330H527N46O207, MW = 8450.9) was synthesized by a new strategy using a combination of microwave-assisted solid-phase synthesis (MA-SPGS) and enzymatic sugar elongation. Synthesis of a key glycopeptide intermediate was best achieved in
C S Lee et al.
Artificial organs, 21(9), 1002-1006 (1997-09-01)
Various modifications of alginate-poly-L-lysine microcapsules were made, such as the inclusion of polyethylenimine (PEI) or carboxyl methyl cellulose (CMC) in the core and the coating of bis(polyoxyethylene bis[amine]) (PEGA) onto the microcapsule membrane surface. A characterization of the modified microcapsules
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Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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