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Merck

One-pot synthesis of simple alkaloids: 2,3-polymethylene-4(3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine.

Chemical & pharmaceutical bulletin (2008-04-02)
Katherine Chae Jahng, Seung Ill Kim, Dong Hyeon Kim, Chang Seob Seo, Jong-Keun Son, Seung Ho Lee, Eung Seok Lee, Yurngdong Jahng
RESUMEN

One-pot synthesis of various 2,3-polymethylene-4(3H)-quinazolinones from anthranilic acid, corresponding lactam and SOCl(2) is described, which can be applicable to the synthesis of simple 4(3H)-quinazolinone-derived alkaloids, such as luotonin A, tryptanthrin, and rutaecarpine.

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Sigma-Aldrich
Tryptanthrin, ≥98% (HPLC)