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Key Documents

Otros documentos

1607007

USP

Saccharin

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

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About This Item

Fórmula empírica (notación de Hill):
C7H5NO3S
Número de CAS:
81-07-2
Peso molecular:
183.18
Beilstein:
6888
Número MDL:
MFCD00005866
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329751066
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

saccharin

fabricante / nombre comercial

USP

mp

226-229 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

formato

neat

cadena SMILES

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

Clave InChI

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Saccharin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Acciones bioquímicas o fisiológicas

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
Precios

1672010

o-Toluenesulfonamide, United States Pharmacopeia (USP) Reference Standard

1672020

p-Toluenesulfonamide, United States Pharmacopeia (USP) Reference Standard

S0050000

Saccharin sodium, European Pharmacopoeia (EP) Reference Standard

PHR1348

Saccharin Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

S0040000

Saccharin, European Pharmacopoeia (EP) Reference Standard

1607040

Saccharin sodium salt dihydrate, United States Pharmacopeia (USP) Reference Standard

1607029

Saccharin hemicalcium salt, United States Pharmacopeia (USP) Reference Standard

PHR1473

o-Toluenesulfonamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1474

p-Toluenesulfonamide, Pharmaceutical Secondary Standard; Certified Reference Material

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The toxicological effects of saccharin in short-term genotoxicity assays.
D L Arnold et al.
Mutation research, 221(2), 69-132 (1989-09-01)
M D Reuber
Environmental health perspectives, 25, 173-200 (1978-08-01)
Saccharin is carcinogenic for the urinary bladder in rats and mice, and most likely is carcinogenic in human beings. The neoplasms of the urinary bladder are malignant and invade and metastasize. Male rats are more susceptible to urinary bladder carcinogenesis
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 225-252 (1996-01-01)
Sodium saccharin (NaSac) produces bladder tumors consistently in male rats only after lifetime exposure that begins at birth. NaSac is not metabolized and is negative in most genotoxicity tests. NaSac-induced cell damage and proliferation have been proposed as important factors
Marilyn E Carroll et al.
Behavioural pharmacology, 19(5-6), 435-460 (2008-08-12)
A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence
L B Ellwein et al.
Critical reviews in toxicology, 20(5), 311-326 (1990-01-01)
Almost from its discovery in 1879, the use of saccharin as an artificial, non-nutritive sweetener has been the center of several controversies regarding potential toxic effects, most recently focusing on the urinary bladder carcinogenicity of sodium saccharin in rats when
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