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1481204

USP

Oxaliplatin

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum

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About This Item

Fórmula empírica (notación de Hill):
C8H14N2O4Pt
Número de CAS:
61825-94-3
Peso molecular:
397.29
Número MDL:
MFCD00866327
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329750629
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

oxaliplatin

fabricante / nombre comercial

USP

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N

InChI

1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1

Clave InChI

ZROHGHOFXNOHSO-BNTLRKBRSA-L

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Oxaliplatin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Oxaliplatin Injection
  • Oxaliplatin for Injection

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

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Y0000271

Oxaliplatin, European Pharmacopoeia (EP) Reference Standard

Y0000275

Dichlorodiaminocyclohexaneplatinum, European Pharmacopoeia (EP) Reference Standard

Y0000273

Oxaliplatin impurity C, European Pharmacopoeia (EP) Reference Standard

Y0000274

Oxaliplatin impurity D, European Pharmacopoeia (EP) Reference Standard

Y0000272

Oxaliplatin impurity B, European Pharmacopoeia (EP) Reference Standard

1481226

Oxaliplatin Related Compound B, United States Pharmacopeia (USP) Reference Standard

1481215

Oxaliplatin Related Compound A, United States Pharmacopeia (USP) Reference Standard

1481237

Oxaliplatin Related Compound C, United States Pharmacopeia (USP) Reference Standard

1481248

Oxaliplatin Related Compound D, United States Pharmacopeia (USP) Reference Standard

1481306

Oxaliplatin System Suitability, United States Pharmacopeia (USP) Reference Standard

1481260

Oxaliplatin Related Compound F, United States Pharmacopeia (USP) Reference Standard

PHR2545

Oxaliplatin Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogramas

Health hazardCorrosion
GHS08,GHS05

Palabra de señalización

Danger

Clasificaciones de peligro

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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L B J van Iersel et al.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(11), 1557-1563 (2014-08-16)
To improve isolated hepatic perfusion (IHP), we performed a phase I dose-escalation study to determine the optimal oxaliplatin dose in combination with a fixed melphalan dose. Between June 2007 and July 2008, 11 patients, comprising of 8 colorectal cancer and
Maire F Osborn et al.
ACS chemical biology, 9(10), 2404-2411 (2014-07-24)
With the importance of RNA-based regulatory pathways, the potential for targeting noncoding and coding RNAs by small molecule therapeutics is of great interest. Platinum(II) complexes including cisplatin (cis-diamminedichloroplatinum(II)) are widely prescribed anticancer compounds that form stable adducts on nucleic acids.
Jennifer R Deuis et al.
Neuro-oncology, 16(10), 1324-1332 (2014-04-10)
Peripheral neuropathy is the major dose-limiting side effect of cisplatin and oxaliplatin, and there are currently no effective treatments available. The aim of this study was to assess the pharmacological mechanisms underlying chemotherapy-induced neuropathy in novel animal models based on
Hirofumi Yasui et al.
Journal of cancer research and clinical oncology, 141(1), 153-160 (2014-08-12)
The FIRIS study previously demonstrated non-inferiority of IRIS (irinotecan plus S-1) to FOLFIRI (5-fluorouracil/leucovorin with irinotecan) for progression-free survival as the second-line chemotherapy for metastatic colorectal cancer (mCRC) as the primary endpoint. The overall survival (OS) data were immature at
Hailiang Wu et al.
Journal of controlled release : official journal of the Controlled Release Society, 189, 1-10 (2014-06-24)
Nanocarriers have been used for specific delivery of therapeutic agents to solid tumors based on the enhanced permeability and retention in cancerous tissues. Despite metastasis is the main reason of cancer-related death and a priority for nanocarrier-based therapies, the targeting
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