568533-U

Discovery^® HS C18 (5 µm) HPLC Columns

L × I.D. 25 cm × 10 mm, HPLC Column

• Sinónimos: Discovery RP18 HPLC Column
• Código UNSPSC: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Propiedades

• Nombre del producto: Columna para HPLC Discovery^® HS C18, 5 μm particle size, L × I.D. 25 cm × 10 mm
• Materiales: stainless steel column
• Agency: suitable for USP L1
• Línea del producto: Discovery^®
• Características: endcapped
• fabricante / nombre comercial: Discovery^®
• envase: 1 ea of
• Extensión del etiquetado: 20% Carbon loading
• Parámetros: ≤70 °C temp. range; 400 bar pressure (5801 psi)
• técnicas: HPLC: suitable
• L × D.I.: 25 cm × 10 mm
• superficie: 300 m²/g
• cobertura de la superficie: 3.2 μmol/m²
• impurezas: <10 ppm metals
• Matriz: silica gel, high purity, spherical particle platform; fully porous particle
• grupo activo de la matriz: C18 (octadecyl) phase
• tamaño de partícula: 5 μm
• tamaño de poro: 120 Å
• Intervalo de pH operativo: 2-8
• aplicaciones: food and beverages
• técnica de separación: reversed phase

Descripción

Descripción general

Discovery^® HS C18 HPLC column is specifically developed for pharmaceutical analyses and purification.

Aplicación

• Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 phenotyping: This research utilizes the Discovery^® HS C18 HPLC column for its superior selectivity and sensitivity in pharmacogenetic studies, providing vital data for personalized medicine approaches in drug metabolism (Abouir et al., 2024).


• A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies: This study highlights the effectiveness of the Discovery^® HS C18 column in the rapid and accurate analysis of molnupiravir, emphasizing its role in supporting fast-paced pharmaceutical research and development (Reçber et al., 2022).


• Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: This application underlines the Discovery^® HS C18 column′s high sensitivity and robustness in clinical diagnostics, crucial for monitoring therapeutic drugs and their metabolites in complex biological matrices (Maliszewska et al., 2020).

Características y beneficios

• Stable, low bleed for LC-MS applications
• Scalable from analytical to preparatory
• Highly stable to ensure excellent run-to-run and lot-to-lot repducibility
• Higher hydrophobicity for better resolution of difficult analytes

   

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Información legal

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany