W1020

W146 hydrate

≥98% (HPLC)

• Sinónimos: ML056, R-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid hydrate, [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
• Fórmula empírica (notación de Hill): C₁₆H₂₇N₂O₄P · xH₂O
• Número de CAS: 909725-61-7
• Peso molecular: 342.37 (anhydrous basis)
• Número MDL: MFCD16875441
• Código UNSPSC: 12352211
• ID de la sustancia en PubChem: 329830425
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: off-white
• solubilidad: methanol: soluble (with 0.1% TFA)
• emisor: Novartis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O.CCCCCCc1cccc(NC(=O)[C@H](N)CCP(O)(O)=O)c1
• InChI: 1S/C16H27N2O4P.H2O/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);1H2/t15-;/m1./s1
• Clave InChI: DQKSZHVSROOTFY-XFULWGLBSA-N

Descripción

Descripción general

W146 hydrate functions as an orthosteric antagonist. It is associated with blood lymphopenia and lung edema in mice.

Aplicación

W146 hydrate has been used to assess vascular permeability in mice.

Acciones bioquímicas o fisiológicas

Potent S1P(1) competitive antagonist; Ki = 10-77 nM.

Características y beneficios

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable