T8276

Anti-TRPC1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Sinónimos: Transient receptor potential cation channel, subfamily C, member 1
• Número MDL: MFCD02686004
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: lyophilized powder
• reactividad de especies: rat
• técnicas: immunohistochemistry: suitable; western blot (chemiluminescent): suitable
• Nº de acceso UniProt: Q9QX01
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... TRPC1(7220) ; mouse ... Trpc1(22063) ; rat ... Trpc1(89821)

Descripción

Descripción general

Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.

Inmunógeno

Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank^® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus.

Acciones bioquímicas o fisiológicas

Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca²⁺ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.

Forma física

Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Información legal

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Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Pictogramas: GHS06,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301 + H311,H411
• Consejos de prudencia: P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P391 - P501
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2
• Riesgos supl.: EUH032
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges