T7830

TFLLR-NH2 trifluoroacetate salt

>98% (HPLC)

• Sinónimos: L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt, Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
• Fórmula empírica (notación de Hill): C₃₁H₅₃N₉O₆ · xC₂HF₃O₂
• Número de CAS: 1313730-19-6
• Peso molecular: 647.81 (free base basis)
• Número MDL: MFCD05663482
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329826874
• NACRES: NA.77

Propiedades

• Análisis: >98% (HPLC)
• formulario: lyophilized powder
• color: white to tan
• solubilidad: H₂O: >2 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
• InChI: 1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
• Clave InChI: QVNWOGSDGQDGHP-MKVNCOEFSA-N

Descripción

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

Aplicación

TFLLR-NH₂ trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

Acciones bioquímicas o fisiológicas

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

Nota de preparación

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable