T6829

TUG-424

≥98% (HPLC)

• Sinónimos: 3-(4-(o-Tolylethynyl)phenyl)propanoic acid
• Fórmula empírica (notación de Hill): C₁₈H₁₆O₂
• Número de CAS: 1082058-99-8
• Peso molecular: 264.32
• Número MDL: MFCD12912449
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329826854
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• solubilidad: DMSO: >10 mg/mL; H₂O: insoluble
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cc1ccccc1C#Cc2ccc(CCC(O)=O)cc2
• InChI: 1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
• Clave InChI: FODHWOBAQBTTFS-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.

GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H319,H410
• Consejos de prudencia: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves