T1452
TPCA-1
≥95% (HPLC)
Sinónimos:
[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide
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About This Item
Fórmula empírica (notación de Hill):
C12H10FN3O2S
Número de CAS:
Peso molecular:
279.29
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
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Ensayo
≥95% (HPLC)
Formulario
powder
color
white to light brown
solubilidad
DMSO: 5 mg/mL, clear
emisor
GlaxoSmithKline
temp. de almacenamiento
2-8°C
cadena SMILES
NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2
InChI
1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
Clave InChI
SAYGKHKXGCPTLX-UHFFFAOYSA-N
Aplicación
TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells.
Acciones bioquímicas o fisiológicas
IKK-2 Inhibitor
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.
Características y beneficios
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Nota de preparación
TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Equipo de protección personal
dust mask type N95 (US), Eyeshields, Gloves
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