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Merck
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T1452

Sigma-Aldrich

TPCA-1

≥95% (HPLC)

Sinónimos:

[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide

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About This Item

Fórmula empírica (notación de Hill):
C12H10FN3O2S
Número de CAS:
507475-17-4
Peso molecular:
279.29
Número MDL:
MFCD09037541
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329826675
NACRES:
NA.77

Análisis

≥95% (HPLC)

formulario

powder

color

white to light brown

solubilidad

DMSO: 5 mg/mL, clear

emisor

GlaxoSmithKline

temp. de almacenamiento

2-8°C

cadena SMILES

NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2

InChI

1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

Clave InChI

SAYGKHKXGCPTLX-UHFFFAOYSA-N

Aplicación

TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells.

Acciones bioquímicas o fisiológicas

TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.

Características y beneficios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparación

TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Molecular pharmacology, 69(6), 1791-1800 (2006-03-07)
Nuclear factor kappaB (NF-kappaB) is a transcription factor believed to be central in the expression of numerous inflammatory genes and the pathogenesis of many respiratory diseases. We have previously demonstrated increased NF-kappaB pathway activation in a steroid-sensitive animal model of
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Oncotarget, 8(29), 47305-47316 (2017-05-19)
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