SRP8043

APRIL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)

• Sinónimos: ACRP30headless:A-proliferation-inducing ligand, ACRP30headless:APRIL, ACRP30headless:CD256, TNFSF10
• Código UNSPSC: 12352200
• NACRES: NA.32

Propiedades

• origen biológico: mouse
• recombinante: expressed in HEK 293 cells
• etiqueta: FLAG^® tagged
• Ensayo: >95% (SDS-PAGE)
• Formulario: lyophilized
• mol peso: ~34 kDa by SDS-PAGE
• envase: pkg of 10 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• impurezas: <0.02 EU/μg endotoxin, tested
• color: white
• Nº de acceso UniProt: Q9D777
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: mouse ... Tnfsf13(69583)

Descripción

Descripción general

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

Forma física

Lyophilized from PBS.

Reconstitución

Reconstitute with 100 μL deionized water.

Otras notas

The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG^®-tag.

Información legal

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable