SRP8030

Fn14 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

• Sinónimos: CD266, E1A-associated protein p300, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A
• Código UNSPSC: 51111800
• NACRES: NA.32

Propiedades

• origen biológico: human
• recombinante: expressed in HEK 293 cells
• Ensayo: >95% (SDS-PAGE)
• Formulario: lyophilized
• mol peso: ~35 kDa by SDS-PAGE
• envase: pkg of 50 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• impurezas: <0.1 EU/μg endotoxin, tested
• color: white
• Nº de acceso UniProt: Q9NP84
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... TNFRSF12A(51330)

Descripción

Descripción general

TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Forma física

Lyophilized from PBS.

Reconstitución

Reconstitute with 50 μL deionized water.

Otras notas

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable