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Merck
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SRP8003

Sigma-Aldrich

Clusterin (nuclear form) mouse

>90% (SDS-PAGE), recombinant, expressed in E. coli, His tagged, liquid

Sinónimos:

Apolipoprotein J, CLI, Lymphocyte antigen 52 (Ly-52), SGP-2, TRPM-2

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

product name

Clusterin (nuclear form) mouse, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

origen biológico

mouse

recombinante

expressed in E. coli

etiqueta

His tagged

Análisis

>90% (SDS-PAGE)

formulario

liquid

mol peso

~45 kDa by SDS-PAGE

envase

pkg of 50 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

concentración

≥0.2 mg/mL

impurezas

<1 EU/μg endotoxin, tested

color

clear

Nº de acceso UniProt

Q06890

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

mouse ... Clu(12759)

Descripción general

Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.

Acciones bioquímicas o fisiológicas

Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer′s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.

Forma física

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

Otras notas

Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis.
Jung GS
PLoS ONE, 9, e105635-e105635 (2014)
Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response.
Afanasyeva MA, et al.
PLoS ONE, 9, e98349-e98349 (2014)
Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis.
Byun K, et al.
The Embo Journal, 15, 801-801 (2014)
Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment.
Hong GH, et al.
Journal of Immunology, 196, 2021-2021 (2001)
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.
Caccamo AE, et al.
Cell Death and Differentiation, 12, 101-101 (2005)
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