SRP6499

HAVCR1/KIM1/TIM1 human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Sinónimos: HAVCR, HAVCR-1, Hepatitis A virus cellular receptor 1, TIMD-1, TIMD1
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• origen biológico: human
• recombinante: expressed in HEK 293 cells
• etiqueta: 6-His tagged (C-terminus)
• Ensayo: ≥90% (SDS-PAGE)
• Formulario: lyophilized
• mol peso: calculated mol wt 31.3 kDa; observed mol wt 80-100 kDa by SDS-PAGE (reducing) (DTT-reduced.)
• envase: pkg of 10 and 50 μg
• impurezas: <1 EU/μg endotoxin (LAL test)
• Nº de acceso UniProt: Q96D42
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... HAVCR1(26762)

Descripción

Descripción general

Hepatitis A virus cellular receptor 1 also known as HAVCR1, HAVCR, KIM1, TIM, TIM1, TIMD1, is widely expressed with highest levels in kidney and testis. The protein encoded by HAVCR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. HAVCR1 may play a role in T-helper cell development, the regulation of asthma and allergic diseases and in kidney injury and repair. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.

Forma física

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable