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Merck
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Documentos clave

SRP6161

Sigma-Aldrich

FGF-7 human

recombinant, expressed in human cells, ≥95% (SDS-PAGE)

Sinónimos:

Fibroblast growth factor 7, HBGF-7, Heparin-binding growth factor 7, KGF, Keratinocyte growth factor

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

recombinante

expressed in human cells

Ensayo

≥95% (SDS-PAGE)

Formulario

lyophilized

mol peso

(17 and 30 kDa, monomer, glycosylated)

envase

pkg of 10 μg

técnicas

cell culture | mammalian: suitable

Nº de acceso NCBI

P21781

Nº de acceso UniProt

P21781

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... FGF7(2252)

Descripción general

Fibroblast growth factor-7 (FGF-7) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities. The gene encoding this protein is localized on human chromosome 15q21.1.

Acciones bioquímicas o fisiológicas

Fibroblast growth factor (FGF) family members are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. This protein associates with and activates fibroblast growth factor receptors (FGFRs). Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, re-epithelialization of wounds, hair development and early lung organogenesis.

Forma física

Lyophilized from a PBS solution.

Nota de preparación

Centrifuge the vial prior to opening.

Reconstitución

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
7G08L64500
6M02L64500

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Xiao-Jing Zhu et al.
PLoS genetics, 10(10), e1004687-e1004687 (2014-10-21)
Epidermal stratification of the mammalian skin requires proliferative basal progenitors to generate intermediate cells that separate from the basal layer and are replaced by post-mitotic cells. Although Wnt signaling has been implicated in this developmental process, the mechanism underlying Wnt-mediated
Krijn K Dijkstra et al.
Cell, 174(6), 1586-1598 (2018-08-14)
Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for individual patients and understand determinants of responsiveness are presently lacking. Here, we establish and validate a
The Fibroblast Growth Factor signaling pathway.
Ornitz DM and Itoh N
Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 4(3), 215-266 (2015)
A family-based association study after genome-wide linkage analysis identified two genetic loci for renal function in a Mongolian population.
Park H
Kidney International, 83(2), 285-292 (2013)
Laxmi Yeruva et al.
mBio, 5(3), e01241-e01214 (2014-06-26)
It is not currently possible to predict the probability of whether a woman with a chlamydial genital infection will develop pelvic inflammatory disease (PID). To determine if specific biomarkers may be associated with distinct chlamydial pathotypes, we utilized two Chlamydia
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