SRP5308

c-KIT (T670E), active, GST tagged human

PRECISIO^®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinónimos: CD117, PBT, SCFR
• Código UNSPSC: 12352200
• NACRES: NA.32

Propiedades

• recombinante: expressed in baculovirus infected Sf9 cells
• Línea del producto: PRECISIO^®
• Ensayo: ≥70% (SDS-PAGE)
• Formulario: buffered aqueous glycerol solution
• actividad específica: 3.8-5.8 nmol/min·mg
• mol peso: ~73 kDa
• Nº de acceso NCBI: NM_000222
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... KIT(3815)

Descripción

Descripción general

c-KIT (T670E) is the human homolog of the proto-oncogene c-kit which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT (T670E) is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT (T670E) function in hematopoiesis, melanogenesis, and gametogenesis and mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. c-KIT (T670E) signaling is involved in human skin pigmentation and that this signaling pathway is regulated by sKIT. It is also help in regulating primordial germ cell growth.

Forma física

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Nota de preparación

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Información legal

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable