SRP5304

PDGFR-α (T674I), active, GST tagged human

PRECISIO^®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinónimos: CD140A, MGC74795, PDGFR2, Rhe-PDGFRA
• Código UNSPSC: 12352200
• NACRES: NA.32

Propiedades

• recombinante: expressed in baculovirus infected Sf9 cells
• Línea del producto: PRECISIO^®
• Ensayo: ≥70% (SDS-PAGE)
• Formulario: buffered aqueous glycerol solution
• actividad específica: 16-24 nmol/min·mg
• mol peso: ~95 kDa
• Nº de acceso NCBI: NM_006206
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... PDGFRA(5156)

Descripción

Descripción general

PDGFR alpha (platelet-derived growth factor receptor a) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFR alpha has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFR alpha in renal cell types involved in fibrotic and sclerosing processes. PDGF and its receptor PDGFR alpha are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase. PDGFRa(T674I) is one of the mutant forms of PDGFRa.

Forma física

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Nota de preparación

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Información legal

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable