SRP5148
Tubulin, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
M40, MGC117247, MGC16435, OK/SW-cl.56, TUBB, TUBB5
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About This Item
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥70% (SDS-PAGE)
Formulario
buffered aqueous glycerol solution
mol peso
~76 kDa
Nº de acceso NCBI
aplicaciones
cell analysis
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... TUBB(203068)
Descripción general
Tubulin-β 1 (TUBB1) protein is a major constituent of microtubules. Previous work suggested that the "microtubule binding domain" of tau (composed of three or four imperfect 18-amino acid repeats, separated by 13- or 14-amino acid inter-repeat regions) can bind to the C-terminal ends of both α and β tubulin monomers. It is found in hematopoietic cells and platelet marginal bands. The gene encoding TUBB1 is localized on human chromosome 6p21.
Aplicación
GST tagged tubulin has been used in Western blotting and in mass spec as a control.
Acciones bioquímicas o fisiológicas
Tubulin-β 1 (TUBB1) interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. It has a role in the formation of the cytoskeleton. Studies revealed that TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded that TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance.
Forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparación
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Root morphogenic pathways in Eucalyptus grandis are modified by the activity of protein arginine methyltransferases
Krista l
BMC plant biology (2017)
The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance
Andreas Prokop
Neural Dev. (2013)
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP)
Paula A
British Journal of Haematology (2013)
An expressed beta-tubulin gene, TUBB, is located on the short arm of human chromosome 6 and two related sequences are dispersed on chromosomes 8 and 13.
Floyd_smith G
Experimental Cell Research (1986)
Helen K Berrieman et al.
The Lancet. Oncology, 5(3), 158-164 (2004-03-09)
beta-tubulin is the target of various antitubulin agents used in the treatment of cancer. After beta tubulin was shown to confer resistance to antitubulin agents in established cell lines, several studies have investigated the DNA sequence of this compound in
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