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SRP5014

Sigma-Aldrich

CK1 δ, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

CK1D, CSNK1D, HCKID

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.77

recombinante

expressed in baculovirus infected Sf9 cells

Línea del producto

PRECISIO® Kinase

Análisis

≥70% (SDS-PAGE)

formulario

buffered aqueous glycerol solution

actividad específica

70-94 nmol/min·mg

mol peso

~72 kDa

Nº de acceso NCBI

NM_001893

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... CSNK1D(1453)

Descripción general

Casein kinase 1 δ (CK1δ) is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair.

Acciones bioquímicas o fisiológicas

CK1δ is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CK1d is activated by CCK2R and it then phosphorylates polycystin 2 (PKD2) at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CKId can phosphorylate in vitro deoxycytidine kinase (dCK), which is a key enzyme in the salvage of deoxynucleosides. Phosphorylation of dCK by CKId in vitro correlates with increased activity of this enzyme.

Forma física

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Nota de preparación

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Información legal

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF?-TRCP
Bin Zhao
Genes & Development (2010)
The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis
Uwe Knippschild
Frontiers in Oncology (2014)
Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2
J. von Blume
The Embo Journal (2007)
Caroline Smal et al.
Archives of biochemistry and biophysics, 502(1), 44-52 (2010-07-20)
Deoxycytidine kinase (dCK) is a key enzyme in the salvage of deoxynucleosides and in the activation of several anticancer and antiviral nucleoside analogues. We recently showed that dCK was activated in vivo by phosphorylation of Ser-74. However, the protein kinase
J von Blume et al.
The EMBO journal, 26(22), 4619-4633 (2007-10-27)
Protein kinase D2 (PKD2), a member of the PKD family of serine/threonine kinases, is localized in various subcellular compartments including the nucleus where the kinase accumulates upon activation of G-protein-coupled receptors. We define three critical post-translational modifications required for nuclear

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