SRP4928
Lipocalin-2 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinónimos:
25 kDa α-2-microglobulin-related subunit of MMP-9, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, p25
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Análisis
≥95% (HPLC)
≥95% (SDS-PAGE)
formulario
lyophilized
mol peso
~20 kDa
envase
pkg of 50 μg
técnicas
activity assay: suitable
impurezas
endotoxin, tested
Nº de acceso NCBI
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... LCN2(3934)
Descripción general
Research area: Cell signaling. The gene LCN2 (lipocalin 2) is mapped to human chromosome 9q34. LCN2, a secreted glycoprotein, is an adipokine. It is expressed by many cells, such as respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells, and cardiomyocytes. LCN2 belongs to the lipocalin family. LCN2 consists of the lipid binding domain that binds to small hydrophobic molecules and the ligand binding cavity that binds to bacterial and mammalian proteins called siderophores.
Aplicación
LCN2 (lipocalin 2)-human has been used in the cell proliferation assay.It has also been used in conductometric immunoassay in renal carcinoma cells.
Acciones bioquímicas o fisiológicas
LCN2 (lipocalin 2) potentially connects obesity and its related adipose inflammation. LCN2 has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. It is an early marker of acute kidney injury, cardiovascular diseases, lupus nephritis, and intestinal inflammation. LCN2 is upregulated in humans with heart failure. It can associate with MMP9 (matrix metalloproteinase-9) and controls its stability. Changes in the expression of LCN2 are associated with many cancers, including breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder, and kidney cancers.LCN2 acts as a pleiotropicmolecule and plays a role in several pathophysiological and physiologicalactivities including immune response, inflammation, metabolic homeostasis, andinfection.
Forma física
Lyophilized with no additives.
Reconstitución
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Gordon P Otto et al.
PloS one, 10(4), e0124429-e0124429 (2015-04-22)
Acute kidney injury (AKI) during sepsis is common and underestimated. Plasma neutrophil gelatinase-associated lipocalin (plasma-NGAL) is discussed as new biomarker for AKI diagnosis, but during inflammation its function and diagnostic impact remain unclear. The association between plasma-NGAL and inflammatory markers
Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-?B inhibitor BRM270 in a xenograft model of lung adenocarcinoma.
International Journal of Oncology, 48, 84-98 (2016)
Guoliang Wang et al.
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Wu B
Scientific Reports, 4, doi: 10-doi: 10 (2014)
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.
Catalan V
Journal of Molecular Medicine, 87, 803-813 (2009)
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