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SRP4915

Sigma-Aldrich

Vaspin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

Sinónimos:

OL-64, SERPINA12, Serpin A12 precursor, Vaspin, Visceral adipose tissue- derived serine protease inhibitor, Visceral adipose-specific serpin

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

Análisis

≥90% (HPLC)
≥90% (SDS-PAGE)

formulario

lyophilized powder

mol peso

~47.0 kDa

envase

pkg of 25 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

impurezas

endotoxin, tested

Nº de acceso NCBI

Q8IW75

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... SPA12(145264)

Descripción general

Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.

Acciones bioquímicas o fisiológicas

Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.

Forma física

1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.

Reconstitución

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

nwg

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Feihong Yang et al.
Biochemical and biophysical research communications, 503(2), 501-507 (2018-05-08)
Visceral adipose tissue-derived serine protease inhibitor (vaspin), as a secretory adipokine, was reported to exert a protective role on insulin resistance. Recent studies showed that serum vaspin level was downregulated in patients with coronary artery disease. However, whether vaspin exerted
Vaspin as a Prognostic Marker in Patients with Acute Myocardial Infarction.
Zhang B
Heart, Lung & Circulation, 25(3), 257-264 (2016)
Vaspin: a novel adipokine, member of the family of serine protease inhibitors
Ekaterini Koiou
Aristotle University Medical Journal, 38.3, 7-18 (2011)
The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis.
Dimova R and Tankova T
BioMed Research International, 823481-823481 (2015)
Association between vaspin level and coronary artery disease in patients with type 2 diabetes.
Hao F
Diabetes Research and Clinical Practice, 113, 26-32 (2016)
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