SRP4171
IL-15 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinónimos:
IL 15, IL-T, Interleukin 15
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About This Item
Productos recomendados
origen biológico
mouse
recombinante
expressed in E. coli
Ensayo
≥98% (HPLC)
≥98% (SDS-PAGE)
Formulario
lyophilized
mol peso
~13.3 kDa
envase
pkg of 10 μg
condiciones de almacenamiento
avoid repeated freeze/thaw cycles
impurezas
endotoxin, tested
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Il15(16168)
Descripción general
IL15 (interleukin 15) protein is a short-chain α-helical bundle type 1 T cell-stimulating cytokine. It is a pleiotropic cytokine belonging to the cytokine receptor γ chain family, and is expressed by dendritic cells (DCs), epithelial cells, macrophages, monocytes, and fibroblasts. IL15, along with its receptor IL15Rα, are co-expressed majorly by activated monocytes and DCs (dendritic cells). Recombinant mouse IL-15 is a 13.3 kDa protein containing 115 amino acid residues.
Acciones bioquímicas o fisiológicas
IL15 (interleukin 15) and IL2 are the only two known cytokine till date that bind to T-cells through IL-2Rβ (IL2 receptorβ). It interacts with lymphocytes via the heterotrimeric IL-15 receptor (IL-15R) composed of IL-15Rα, IL-2 receptor beta (IL-2Rβ), and IL-2 receptor gamma (IL-2Rγ). Since, IL-2R and IL-15R have common subunits, it is supposed that IL2 and IL15 perform similar functions, such as induction of lymphocyte activation and proliferation in vitro, and apoptosis of activated lymphocytes (AICD). However, unlike IL2, IL15 mimics the function of IFN I (interferon) by potently and selectively activating memory-phenotype CD44hi CD8+ cells.
Forma física
Lyophilized from 10 mM Tris, pH 8.0.
Reconstitución
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 μg/μL. The solution can then be diluted into other aqueous buffers.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.
Schluns KS, et al.
Journal of Immunology, 168(10), 4827-4831 (2002)
Anne L Ruiz et al.
Nature communications, 5, 5150-5150 (2014-10-07)
Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction
Jianmiao Wang et al.
American journal of respiratory cell and molecular biology, 53(6), 822-833 (2015-04-30)
Virus-induced exacerbations often lead to further impairment of lung function in chronic obstructive pulmonary disease. IL-15 is critical in antiviral immune responses. Retinoic acid (RA) signaling plays an important role in tissue maintenance and repair, particularly in the lung. We
Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.
Yu H, et al.
PLoS ONE, 10(11) (2015)
Ai Omi et al.
European journal of immunology, 44(9), 2638-2647 (2014-07-06)
Mature NK cells are heterogeneous as to their expression levels of cell surface molecules. However, the functional differences and physiological roles of each NK-cell subset are not fully understood. In this study, we report that based on the Ly6C expression
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