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Merck
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Documentos clave

SRP4121

Sigma-Aldrich

IGF-I from rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sinónimos:

IGF-I, IGF1, IGFIA, Somatomedin C

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About This Item

Número MDL:
MFCD00081716
Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

rat

recombinante

expressed in E. coli

Análisis

≥95% (HPLC)
≥95% (SDS-PAGE)

formulario

lyophilized

mol peso

~7.69 kDa

envase

pkg of 20 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

impurezas

endotoxin, tested

Nº de acceso NCBI

P08025

Nº de acceso UniProt

P08025

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

rat ... Igf1(24482)

Descripción general

IGF-I (insulin-like growth factor-I) is a member of a family of polypeptide growth factors. Rat IGF-I is a 7.69kDa protein containing 70 amino acid residues.
IGF-I exists in two isoforms (IGF1A and IGF1B) in mouse due to alternative transcription.

Aplicación

IGF-I (Insulin-like Growth Factor-I) from rat has been used to study the the effect of IGF-I, IL-27 (interleukin-27) and IL-35 on the blood flow in the inflamed joints of rats.
IGF-I from rat has also been used to test its effect on the expression of its receptor in rheumatoid arthritis model.

Acciones bioquímicas o fisiológicas

IGF-I (Insulin-like growth factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It mainly mediates growth and development. IGF-I is required for fetal growth and development. It is also involved in the growth and repair of heart tissues. IGF-I has been linked to neuroplasticity and hippocampal neurogenesis. It is important in the recovery from ischaemic injury.
IGF-I interacts with interleukins IL-27 and IL-35 and may play a role in chronic joint inflammation.

Forma física

Lyophilized without additives.

Reconstitución

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
Houshmandi N
Cytokine, 81, 117-126 (2016)
Glucose metabolism and hepatic Igf1 DNA methylation are altered in the offspring of dams fed a low-salt diet during pregnancy.
Siqueira FR
Physiology & Behavior, 154, 68-75 (2016)
Aimee J Varewijck et al.
European journal of endocrinology, 173(2), 119-127 (2015-05-08)
Previously we demonstrated that IGF1 receptor stimulating activity (IGF1RSA) offers advantages in diagnostic evaluation of adult GH deficiency (GHD). It is unknown whether IGF1RSA can be used to monitor GH therapy. To investigate the value of circulating IGF1RSA for monitoring
María Llorens-Martín et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 15(2), 134-148 (2009-03-25)
This review addresses the role of serum insulin-like growth factor 1 (IGF1) as one mechanism of adult neural plasticity, specifically, its regulation of hippocampal neurogenesis among other plasticity-related processes. It is suggested that IGF has been reused advantageously both for
He He et al.
Inflammation, 38(6), 2178-2184 (2015-06-25)
Sepsis-induced myocardial injury (SIMI) is caused by various mechanisms. The aim of this study was to investigate the effects of salidroside (Sal) on SIMI and its mechanisms in rats. The sepsis model was established by intraperitoneal injection of lipopolysaccharide (LPS)
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