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Key Documents

SRP3275

Sigma-Aldrich

IL-33 human

Animal-component free, ≥98% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized

Sinónimos:

NF-HEV

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

product name

IL-33 human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

origen biológico

human

recombinante

expressed in E. coli

Análisis

≥98% (HPLC)
≥98% (SDS-PAGE)

formulario

lyophilized

potencia

≥0.05 ng/mL ED50

mol peso

17.9 kDa

envase

pkg of 10 μg

impurezas

<0.1 EU/μg endotoxin, tested

color

white to off-white

Nº de acceso UniProt

O95760

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IL33(90865)

Categorías relacionadas

Descripción general

It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities.

Acciones bioquímicas o fisiológicas

Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. Recombinant human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

Forma física

Lyophilized from 10 mM Sodium Phosphate, pH 8.0 + 0.5 mM DTT.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ying Lei et al.
PloS one, 10(7), e0133774-e0133774 (2015-07-28)
In several clinical and experimental studies IL-33 and its receptor have been found to play important roles in the development of asthma and allergic airway inflammation. We evaluated the effects of vaccination against IL-33 in a mouse model of airway
Elizabeth A Oczypok et al.
The Journal of allergy and clinical immunology, 136(3), 747-756 (2015-05-02)
Single nucleotide polymorphisms in the human gene for the receptor for advanced glycation end-products (RAGE) are associated with an increased incidence of asthma. RAGE is highly expressed in the lung and has been reported to play a vital role in
Jochen Schmitz et al.
Immunity, 23(5), 479-490 (2005-11-16)
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human inflammatory diseases. Within the
Rebecca L Maywald et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(19), E2487-E2496 (2015-04-29)
Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by nonepithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and metastasis. Here
Xi-Xiang Yu et al.
Digestive diseases and sciences, 60(5), 1265-1272 (2015-02-07)
As a pro-inflammatory cytokine, IL-33 has been demonstrated to play an important role in tumor progression. It is reported that IL-33 is highly expressed in the serum and tumor tissues of patients with gastric cancer. However, the function of IL-33
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